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Published 13:25 15 Mar 2018 GMT
Updated 17:33 15 Mar 2018 GMT
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Cork native and Glamour magazine's editor-in-chief Samantha Barry will appear on the chat show to talk about how her award-winning career that has taken her across the globe.
And she'll also be spilling the beans about what it's like rubbing shoulders with Anna Wintour on the front row at New York Fashion Week and interviewing Donald Trump in a toilet in Miami.
Game of Thrones' Liam Cunningham will also be in the Late Late studio this week, chatting about leading the St Patrick's Day Festival this year - as well as the end of the HBO hit series.
The passionate human rights advocate will also be sharing everything he learned on a recent trip to Uganda and giving his thoughts on the scandals engulfing some of the charity organisations working in the developing world.
And as Daffodil Day approaches, Ryan will be joined in studio by some of those who have contributed to or benefitted from the fundraising and work carried out by the Irish Cancer Society.
He will also be chatting to Liam and Paddy Doran, boxers and members of the travelling community, who are in the new fashion campaign for British menswear brand Kent & Curwen.There will also be music from Don McLean and Jake Carter during the episode.

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