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Published 07:01 29 Jun 2022 BST
Updated 07:30 29 Jun 2022 BST
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The message shared to her Instagram account read: "Dame Deborah James.
"We are deeply saddened to announce the death of Dame Deborah James; the most amazing wife, daughter, sister, mummy. Deborah passed away peacefully today, surrounded by her family.
"Deborah, who many of you will know as Bowelbabe, was an inspiration and we are incredibly proud of her and her work and commitment to charitable campaigning, fundraising and her endless efforts to raise awareness of cancer that touched so many lives.
"Deborah shared her experience with the world to raise awareness, break down barriers, challenge taboos and change the conversation around cancer. Even in her most challenging moments, her determination to raise money and awareness was inspiring.
"We thank you for giving us time in private as a family, and we look forward to continuing Deborah’s legacy long into the future through the @bowelbabefund
"Thank you for playing your part in her journey, you are all incredible.
"And a few final things from Deborah…'find a life worth enjoying; take risks; love deeply; have no regrets; and always, always have rebellious hope. And finally, check your poo – it could just save your life.' x"
Deborah leaves behind husband Sebastian Bowen, their two children as well as family, friends, colleagues and thousands of followers.
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